Application Question 6- Acne

 
Application Question 6

    Due Feb 11 by 11:59pm Points 10 Submitting a text entry box Available until Mar 26 at 1pm

This assignment was locked Mar 26 at 1pm.

Now that you have had an opportunity to reflect on this question and get some ideas from colleagues, take this opportunity to more formally record a response.

acnePretend a friend tells you, “I can’t believe I still get pimples even though I’m not a kid anymore! My doctor keeps telling me not to poke or scratch at my pimples, but I always want to just get them off!”

Use an A&P perspective to explain why your friend’s doctor would say to not poke or scratch pimples. Use the words “myofibroblasts,”  “collagen,” and "migrate" in your answer.

Feel free to refer to the journal article excerpt

Download journal article excerpt about "wound healing vs. fibrosis," the last segment of the Zoom recording from class.

Mostly Complete (10 pts): Include myofibroblasts, collagen, and migrate in your response. In particular discuss the special characteristics of myofibroblasts and how this situation could lead to excess collagen production and that would form a scar.  Refer to the article linked above and especially some of the info at the end about how/why fibrosis occurs. There are some specific roles for collagen, especially, that might occur if this person is constantly irritating the skin.

Partially Complete (6 pts): Discuss relevant information related to the three key terms, but answer does not connect excess collagen production to the scenario/fibrosis.

         When you scratch a wound, it disrupts the delicate balance of skin cells and collagen fibers involved in the repair process. While wound healing is essential, chronic inflammation and excessive repair can trigger the accumulation of extracellular matrix (ECM). Myofibroblasts, responding to chemical signals, migrate to the wounded area and produce collagen and other extracellular matrix proteins. Although myofibroblasts play a role in wound contraction, their persistent presence can lead to excessive scar tissue formation, known as fibrosis. This occurs when the synthesis of new collagen by myofibroblasts exceeds the rate at which it is degraded, resulting in an overall increase in collagen content over time.Continuously scratching the healing process disrupts the formation of smooth collagen, leading to irregular scar tissue and permanent scarring. Therefore, doctors advise against poking or scratching pimples, as it not only worsens inflammation but also contributes to fibrosis or scarring.