Skeletal Muscle Structure

myosin

 myosin   

 

1. A fibrous  protein that forms
2.  contractile filaments of muscle cells
3.  involved in motion in other types of cells.

shape and size 

• Myosin filament is 1.6 μm in length, approximately 300 Å in diameter and has an axial repeat of 429 Å along its length
  

 fumction-  motor protein

1. prototype of a molecular motor
2.  converts chemical energy in the form of ATP to mechanical energy,
3.  contraction of a muscle cell and allow bodies to move or perform an action.
4.  

• In the relaxed state, 
• the muscle fiber is at rest.
• Positively charged sodium ions (Na+) enter the local membrane of the fiber, causing depolarization.
• calcium ions (Ca++) from storage in the sarcoplasmic reticulum (SR) occurs.
• the muscle fiber maintains its original length.
•  

1. contracted state the muscle continues to shorten.

acting- coin spiral different lengh

acting filament 

cont

troponin

complex protein 

cardiac muscle 

skeleton muscle 

troponin 3 type troponin I, troponin T, and troponin C

prevent contraction 

tropomyosin 

1.  prevent mu,scle contracting at the wrong time 
2. 
   

titin

is the biggest protein 

Rigormotis

 What will you be able to do?

After class (this week & next!), you will be able to:

• Explain how various poisons impact muscle contraction at the level of the neuromuscular junction.
• Apply an understanding of muscle fiber physiology to describe changes to muscles in exercise and diseases.

Have you heard the term

"rigor mortis?" If so, what does it mean?

Muscle9

ACh molecule stay there forever

Enzyme 

No longer attached to muscle

ACHE enzymes special effect to relax muscle

 Muscle 

Toxin

Poison 

Neumuscular toxin

Various poison affect muscle contraction

Neuron come out for spinal cord 

Motor

Axon terminals end of neuron

Neuromuscular junction

Neuron membrane

Muscle membrane 

Double line membrand of neuron 

Another double line 

Water and oil don’t mix very well

Ca++-> hydrophilic 

Lots of calcium 

Water behind 

Signal come in 

Water niteasy to go i tothe fatty membrane 

How neuromuscular toxin can distrupt 

Rigor motis 

Muscle Fibers single muscle cell

Sarcalemma 

Muscle physiology 

Relax to do contractions 

ATP base active transport pump

ACH

Cells using ATP 

Water behind the dam 

Blocked out all cell membrane 

Active transport

SR sarcoplasmic reticulum

Tropnin 

JTropomyosin

AAnd P muscle contraction 

Myofibrils 

Sarcomere definition to read 

Feedback loop week 8

 Chondrocytes 

Osteoblast 

Bone tissue Long bone

Synovial add a new cell in cell division ( chondrocytes) making the bone longer pushed the old cellaway

Bone tissue and osteoblasts

Adding cartilage tissue 

Osteo blast

Cartilage effect lengthen the bone