Application 8

 (available for up to 7/10
Thanks for sharing your diagram! Please double check the locations of all 8 cells, including which ones belong in the epidermis vs. dermis, and which specifically would be found next to one another in the stratum basale. Can you also show something about what's happening to the cells in this problem and what the problem might be? Some resources for this are linked in the grading rubric underneath the question.

 Before we move on to some new topics about the skin, let's take a moment to reflect on our discussions in our last class meeting.  Feel free to look back at your notes or the Zoom recording of the last meeting to refresh your memory!

Some sort of disease, injury, or infection has afflicted someone’s skin! Your job is to figure out what’s going on and show your evidence for conclusion.

Keratinocyte is the most important cells in the epidermis, it play a vital role in maintaining skin integrity.Disruptions in desmosomes compromise tissue integrity, affecting skin.According to the clues when tissue is damaged, blood vessels widen, leading to bleeding.The injured area releases fluid, initiating the healing response.Langerhans cells plays essentials roles it defense against pathogen present in the enviroment. When the tissue is damage it migrate to the wound site capture antigens from the wound and initiating an immune response , communicate with keratinocytes and fibroblasts.Cytokines act as beacons,  directing white blood cells (WBCs) to  the right place to combat infections and promote tissue healing. Keratinocytes,  migrate to the wound edge, actively participating in re-epithelialization. Keratinocytes stem cells played vital roles in the wound healing process to ensure skin remains resilient and protected.Keratinocytes ensure the wound remains covered.Merkel cells communicate with nearby cells, including keratinocytes and fibroblasts. Fibroblasts synthesize collagen, providing strength and structure to the healing tissue.Epithelial cells move toward the injury area, covering the wound.Melanocytes contribute to scar pigmentation.Scar tissue often contains melanin, which affects the scar’s color.

Melanocyte:  Melanin protects our skin from UV radiation, abnormal melanocytes can lead to various consequences and skin conditions such as freckles , melanoma , age spot , genetic mutations , melasma.

Langerhans Cell:Langerhans cells help prevent autoimmunity, an immune response against healthy cells. Langerhans cells take center stage, their abnormal behavior affecting organs and quality of life.

Fibroblast: There’s a need for a small amount of new dermal protein fibers. 

Dermal Dendritic Cell: No unusual activity requiring my services. Merkel Cell: Sensed a sudden increase in pressure in one area of the skin.

 Lamellated Corpuscle: No signals out of the ordinary.

Using a spare piece of pape

r or an index card or post it, create a diagram of the skin based on the clues. All 8 cell types and information from the clues should be represented. Show or label your idea of what the skin problem is!

Take a picture of your diagram and upload it here.

Don't spend too much time on the artistry!  Remember that we started this together during Zoom and I showed some ways to do this with simple lines and abbreviations!

Note: This is intended to be done on paper, not on a computer. If you're using the Canvas phone/table app, you can take a picture of your diagram with your device and upload it directly from there within the Canvas app.  If you're not using the app, you can send the picture to yourself by email and then upload it here on your computer.

Mostly Complete (10 pts): Diagram shows all 8 cell types in their appropriate positions/layers.  To clarify the locations of cells, check the location information in the clues in this sorting activity
Links to an external site..  You might compare those location descriptions to a diagram of the skin's layers, such as this one

Links to an external site..  Diagram shows or mentions a reasonable injury, disease, or infection based on the evidence in the clues.

Partially Complete (6 pts): One or more of the 8 cell types is not shown or appears in the wrong location in diagram.  Or information on a skin problem related to clues is absent.

 I would like to explain to Luis that, bone growth and elongation are made by the chondrocyte and osteoblast.

 Especially chondrocytes are dividing and lengthening at the end of the bone before puberty and we notice our height is taller. 

Estrogen hormone released at the stage of puberty, and that hormone shortens the life of the chondrocytes that causes the stopping of the bone length.

 When the bone elongation is terminated, osteoblasts start to bind with calcium phosphate to harden the bone. Therefore, we noticed that the height stops at the puberty stage and no longer gets taller. 

During growth, chondrocytes actively produce new cartilage, which is later transformed into bone by osteoblasts. Chondrocytes are specialized cells found in the growth plates of our bones. Osteoblasts play a crucial role in creating new bone tissue, contributing to the lengthening of long bones and our overall height. When puberty begins, the body produces estrogen hormones. As estrogen levels peak, it instructs bone receptors to shut down, allowing bones to settle into their final dimensions. This process explains why significant height changes are less likely after puberty

    I will explain to Luis that during growth, chondrocytes actively produce new cartilage, which is later transformed into bone by osteoblasts.Chondrocytes are specialized cells found in the growth plates of our bones.Osteoblasts play a important role in creating new bone tissue, contributing to the lengthening of long bones and our overall height

when we grow up the chondrocytes actively make new cartilage, which is ultimately transformed into bone by another type of cell known as osteoblasts. Chondrocytes are specialized cells found in the growth plates of our bones.Osteoblasts work hard to create new bone tissue, which lengthens  long bones and contributing to our height.  When puberty start the bodies begin manufacturing estrogen  hormones. The estrogen hormone circulate in our blood when it reach to highest level , which effectively instructs our bone receptors to shut down. So that his bones settled into their final dimensions, and that’s why he hasn’t experienced significant height changes.