Application Question 4 - Disscussion about Cancer

 
Application Question 4

    Due Jan 28 by 11:59pm Points 10 Submitting a text entry box Available until Mar 26 at 1pm

This assignment was locked Mar 26 at 1pm.

Now that you've had a chance to clarify your ideas by reviewing some of your colleagues' responses, take a moment to share some of your final thoughts on the prompt below.

Prompt:

DNA Your friend tells you she recently had genetic testing done, and her doctor said she “inherited a single mutation in a gene that is connected to breast cancer.”

Your friend is unsure what this means and is worried she will definitely get breast cancer later in life.

We’ve now discussed many reasons why your friend would not be 100% guaranteed to get cancer - particularly aggressive cancer - based on just 1 mutation!

Explain at least three specific, cell biology reasons why.

Mostly Complete (10 pts): 

• Discuss the roles of at least three of the following in cancer development: 
• Cyclins
• Oncogenes, 
• Tumor Suppressors,
•  Metastasis, 
• Angiogenesis, 
• Desmosomes/
• Adherens Junctions, 
• Cell Specialization, etc.

Partially Complete (6 pts): Discuss only one or two of the factors above, or discuss three things but with incomplete or incorrect descriptions of their roles.

 

Based on just one genetic mutation my friend may not get cancer.Oncogene is a mutated gene that has the potential to cause cancer. The normal healthy adult their genetic and cellular mechanisms can prevent the growth and spread of the cancer mutation.

Cyclins control the progression of the cell cycle by activating particular enzymes one kinase in humans activates the proteins that carry out DNA replication.In healthy adult the DNA damage everyday which called mismatch ,but  DNA fixed by itself.The error form different form sometime nucleotide match the correct way. Each nucleotide contain base each DNA during replication the enzyme DNA polymerase help to bring the right partner pair with every base. The enzyme catches the mismatch and repair it right away which called mismatch repair.

 The healthy adult body the DNA mismatch repair by it self. Sometime lots of different molecules could cause chemical changes to nucleotide which was the trigger such as exposure from our environment chemicals , substances , UV light, contain chemical compound in smokes that caused DNA damage.  But our body have specific enzyme to reverse or correct the damage. Our body cell also has more general repair pathways . Just one base is damaged it can usually fixed by a process called base excision repair.  

If  double strand DNA is not damage she may not get cancer.   Cancer needs a blood supply to grow or spread  is called angiogenesis. Metastasis is spreading the cancer to other part of the body.