Application Question 3 -Imatinib drug

 This assignment was locked Mar 26 at 1pm.

Now that you've had a chance to think about this and refine your ideas by seeing some colleagues' responses, let's take a chance to record your final (for now) thoughts on this prompt.  I highly encourage you to review your colleagues' responses to in the past discussion before submitting your answer here!

• Imatinib is a drug that is used to treat leukemia.
•   It dissolves easily in water and has been found to build to very high concentrations in diseased cells.

Recall that we discussed four ways materials move across membranes:

1) simple diffusion
2) facilitated diffusion
3) active transport
4) endo/exocytosis.

Refer to this yes/no decision tree

Download yes/no decision tree for determining modes of transportation for chemicals.

Given the information above, you should be able to eliminate some of those 4 methods as possibilities for imatinib.

Which of the four transport methods can you eliminate in this case and how do you know imatinib is not using those transport methods to get through cell membranes?

In case it helps, the slides for this topic can be found here and there's also a video

Links to an external site. about membrane transport.

Mostly Complete (10 pts): Note that because this chemical moves to higher concentrations (goes against concentration gradient) that means it cannot be moving by any form of diffusion.  So we can eliminate BOTH of our forms of diffusion.  The drug is hydrophilic, so that's yet another reason it cannot move by simple diffusion, which is reserved for hydrophobic chemicals.

Click here to see information on revising application questions for additional points

Imatinib drug is easy to dissolved in water , so that it cannot be simple diffusion .  It is not facilitate diffusion because  Imatinib drug build up highly concentration. The molecule is large it cannot across lipid bilayer so that it  need assistant to eliminate  by endo/exocytosis.