Application question 14

 

Step 2: Chemical & Cellular Explanation

2a) Please describe what happens with ATP inside muscle cells in this condition, in your own words?

2b) Describe how those changes in ATP will impact the sarcomere and contraction.

 

Please answer the above questions and label your responses as 2a), 2b), etc. Please keep your answers to 1-2 SENTENCES per question to describe what may be going on!

 Step 2: Chemical & Cellular Explanation
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2a) Please explain what happens with ATP inside muscle cells in this condition, in your own words?

2b) Describe how those changes in ATP will impact the sarcomere and contraction.

 

Answers:

2a) In rhabdomyolysis, ATP becomes depleted from a) sustained contraction and b) overactive ATP-dependent membrane proteins.

2b) Due to abnormal depletion of ATP during rhabdomyolysis, ATP cannot detach the myosin head from actin. This causes a sustained contractile state of the sarcomere.