application 6 revised

Thanks for the response! What special properties do myofibroblasts have over regular fibroblasts?

Looking at the last few sentences of the article we read, what special connections does collagen have to scarring/fibrosis?

 

 

 When you scratch a pimple, you disrupt the delicate balance of skin cells and the collagen fibers involved in the repair process. Wound healing is crucial, but chronic inflammation and excessive repair can lead to the accumulation of extracellular matrix (ECM). Myofibroblasts, which play a role in wound contraction, can persist in tissues and contribute to the formation of excessive scar tissue, known as fibrosis. This occurs when the synthesis of new collagen by myofibroblasts outpaces its degradation, resulting in an overall increase in collagen content over time.

When you scratch a wound, it disrupts the delicate balance of skin cells and collagen fibers involved in the repair process. While wound healing is essential, chronic inflammation and excessive repair can trigger the accumulation of extracellular matrix (ECM). Myofibroblasts, responding to chemical signals, migrate to the wounded area and produce collagen and other extracellular matrix proteins. Although myofibroblasts play a role in wound contraction, their persistent presence can lead to excessive scar tissue formation, known as fibrosis. This occurs when the synthesis of new collagen by myofibroblasts exceeds the rate at which it is degraded, resulting in an overall increase in collagen content over time.Continuously scratching the healing process disrupts the formation of smooth collagen, leading to irregular scar tissue and permanent scarring. Therefore, doctors advise against poking or scratching pimples, as it not only worsens inflammation but also contributes to fibrosis or scarring.

When you scratched it disturb the delicate balance of skin cells and the collagen fiber in repair process. Wound healing is essential, but chronic inflammation and repair that trigger the excessive accumulation of extracellular matrix (ECM). Myofibroblasts migrate to the wounded area, triggered by chemical signals to produce collagen and other extracellular matrix proteins. Myofibroblasts mediate wound contractions, but their persistent presence in tissues leads to excessive scar tissue formation turned out fibrosis.Fibrosis occours when the synthesis of  new collagen by myofibroblasts exceeds the rate of which  is degraded, such that the total amount of collagen increases over time. When you keep scratching it disturb the healing process instead of smooth collagen, it's create irregular scar tissue causing permanent scarring. Thus, the doctor advised not to poke or scratch the pimples because it is not only worsening the inflammation but also caused fibrosis or "scarring."