Week 3 - Physiology of Cancer: Elaborate 2

 

You will receive 1 point for submitting a post of your own, after which you will be able to see your colleagues' posts.

Discussion Prompt:

We are going to refer back once again to our central prompt about cancer and genetic testing:

Your friend tells you she recently had genetic testing done, and her doctor said she /

Your friend is unsure what this means and is worried she will definitely get breast cancer later in life.

We've now discussed many reasons why your friend would not be 100% guaranteed to get cancer - particularly not aggressive cancer - based on just one mutation.  How would you explain at least a few of those reasons to your friend?  You might consider how her risk of cancer relates to topics like:

• Cyclins
• Tumor Suppressors
• Oncogenes
• Cell Specialization
• Angiogenesis
• Metastasis
• Adherens Junctions and Desmosomes

In a moment, I'm going to ask you to share your individual thoughts in an application question.  This discussion is an opportunity to share ideas with some colleagues and get clarifications before responding individually!

 

             Based on just one genetic mutation my friend may not get cancer.Oncogene is a mutated gene that has the potential to cause cancer. The normal healthy adult their genetic and cellular mechanisms can prevent the growth and spread of the cancer mutation. Cyclins control the progression of the cell cycle by activating particular enzymes one kinase in humans activates the proteins that carry out DNA replication.In healthy adult the DNA damage everyday which called mismatch ,but  DNA fixed by itself.The error form different form sometime nucleotide match the correct way. Each nucleotide contain base each DNA during replication the enzyme DNA polymerase help to bring the right partner pair with every base. The enzyme catches the mismatch and repair it right away which called mismatch repair.  The healthy adult body the DNA mismatch repair by it self. Sometime lots of different molecules could cause chemical changes to nucleotide which was the trigger such as exposure from our environment chemicals , substances , UV light, contain chemical compound in smokes that caused DNA damage.  But our body have specific enzyme to reverse or correct the damage. Our body cell also has more general repair pathways . Just one base is damaged it can usually fixed by a process called base excision repair.  

If  double strand DNA is not damage she may not get cancer.   Cancer needs a blood supply to grow or spread  is called angiogenesis. Metastasis is spreading the cancer other part of the body.

  Cyclins control the progression of the cell cycle by activating particular enzymes—cyclin dependent kinases. Those kinases act on different protein structures that play large roles in the cell cycle. For example,