The altoid case

.They can be frozen for extended periods of time and still remain infectious. To destroy a prion it must be denatured to the point that it can no longer cause normal proteins to misfold. Sustained heat for several hours at extremely high temperatures (900°F and above) will reliably destroy a prion

Prion don't really change their shape 

Protein are denatured 

Prion are not easy denatured 

Prion shape might be held together with diffuse covalent bond 

Prion shape much more stable 

Step 2 

GAUCHER’s disease

  Betaglucosidase enzyme  (kind of protein that assist with chemical reactions)