In a positive feedback loop, the response amplifies the initial stimulus, leading to a further increase in the stimulus. In the case of a fever, the elevated body temperature triggers the release of chemicals called pyrogens, which signal the hypothalamus in the brain to raise the body’s set point for temperature. This causes the body to generate and retain more heat, leading to a further increase in body temperature 12.
The human body has a complex mechanism to maintain homeostasis, which is the tendency to resist change in order to maintain a stable, relatively constant internal environment 1. Homeostasis typically involves negative feedback loops that counteract changes of various properties from their target values, known as set points. In contrast to negative feedback loops, positive feedback loops amplify their initiating stimuli, in other words, they move the system away from its starting state 1.
Positive feedback loops are not always harmful. For instance, during childbirth, the hormone oxytocin is released, which stimulates uterine contractions. These contractions push the baby towards the birth canal, leading to more oxytocin release and stronger contractions, until the baby is born 2.
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Higher temperature indicates that primarily in response to an infection. Maintaining high temperature
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