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Sodium ions play a critical role in muscle cell depolarization.Calcium ions are essential for muscle contraction.During normal muscle contraction, sodium channels open, allowing sodium ions to flow into the muscle cell.

Latrotoxin effects affect cell membrane which sodium and calcium currents depolarize the membrane that allow influx of sodium and calcium ions .Binding to Neuronal Receptorsdisrupt normal neuromuscular junction function

Increase calcium ion [Ca2+] ion resulting in increase release ACH  . Excessive release of acetylcholine (ACH) at the neuromuscular junction,   resulting in increase muscle contraction of skeletal muscle and cardiac muscle.