Leukemia

 Leukemia starts in the soft, inner part of the bones (bone marrow), but often moves quickly into the blood. It can then spread to other parts of the body, such as the lymph nodes, spleen, liver, central nervous system and other organs.

Which specimens do you think represent bones in rickets? Why?

Rickets refers to the deficient mineralization alkaline phosphatase (ALP) and defective organization of cartilage at the growth plate and is only seen in children. Because the growth plates at the ends of the long bones are where lengthening of these bones occurs, children with rickets will experience poor height growth.

 

What is the bone pathology in osteogenesis imperfecta?

Osteogenesis imperfecta (OI) is a genetic disorder of connective tissues caused by an abnormality in the synthesis or processing of type I collagen. It is also called brittle bone disease. It is characterized by an increased susceptibility to bone fractures and decreased bone density.Feb 6, 2023

How does osteogenesis imperfecta affect the bones?

In the most common forms, people with OI have a gene that carries incorrect instructions in one copy of the gene for making collagen, a substance that makes bones strong. The gene causes the body to not make enough collagen or the collagen does not work properly. This leads to weak bones that break easily.